查看银屑病关节炎的来源

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您请求的操作仅限于组中的用户:治疗的目标是减轻疼痛、僵硬和肿胀，抑制疾病进展，优化功能，减少疾病的影响，提高患者的生活质量。 waldron N.银屑病关节炎患者的护理与支持。护理标准2012;26:35-39。http://rcnpublishing.com/doi/abs/10.7748/ns2012.08.26.52.35.c9247(accessed 2014年3月20日)。
===轻度疾病=== *非甾体抗炎药(NSAIDS)
*局部皮质类固醇注射(必须小心，因为某些患者可能会引起银屑病发作) '''''注意:'''''非甾体抗炎药或关节内皮质类固醇都不能阻止结构性关节损伤
===中度至重度疾病=== *疾病缓解抗风湿药(DMARD)也称为慢效抗风湿药-这些药物会抑制疾病活动性(SAARD) [http://www.webmd.com/rheumatoid-arthritis/modifying-medications www.webmd.com/rheumatoid-arthritis/modifying-medications] *抗肿瘤坏死因子:如果患者对非甾体抗炎药或DMARDS反应不佳，应使用。这些药物包括阿达木单抗、依那西普、戈利木单抗和英夫利昔单抗[http://www.drugs.com/mtm/infliximab.html www.drugs.com/mtm/infliximab.html]、[http://www.drugs.com/cdi/etanercept.html www.drugs.com/cdi/etanercept.html]、[http://www.drugs.com/cdi/alefacept.html www.drugs.com/cdi/alefacept.html]。这些药物通过静脉注射可以减少t细胞，从而减少肿瘤坏死因子的释放。两者都非常有效，但也有风险，因为它们会削弱免疫系统。[http://www.psoriasisguide.ca/medical_treatment/immunobiologics/biologic_drugs.html www.psoriasisguide.ca/medical_treatment/immunobiologics/biologic_drugs.html]
=== New Drugs === *Otezla是2014年获批用于银屑病关节炎的新药。该药是一种口服磷酸二酯酶-4 (PDE-4)抑制剂，可减少促炎介质，增加抗炎介质。< ref name = "起到了" >起到了推动作用。新闻:银屑病关节炎。 http://www.medscape.com/viewarticle/822396 (accessed 24 Mar 2014)
=== Treatment Options === *Not all treatments that target psoriasis can successfully target PsA as well.  Therefore, using medications that are beneficial for both psoriasis and arthritic impairments are preferred.  Following, is a chart with a proposed algorithm providing recommended treatments for both skin and/or joint diseases based on the impairments of the individual as well as the severity of the diseas. [[Image:Diff2.PNG|577x402px]]Yiping Gan, Emily, Chong, Wei-Sheng, Tey, Hong Liang, Therapeutic Strategies in Psoriasis Patients with Psoriatic Athritis: Focus on new Agents. BioDrugs 2013 27:359-373.http://eds.b.ebscohost.com/ehost/pdfviewer/pdfviewer?sid=8ee565f0-094a-4aab-b969-cadd7ab01765%40sessionmgr113&vid=6&hid=116 (accessed 20 MAR 2013)  *'''Adverse Drug Reactions and Toxicity: '''Most common reactions are malaise, nausea, and hair loss, but others include liver fibrosis, infection, GI ulcers, elevated transaminases,  bone marrow suppression, interstitial pneumonitis, and alveolitis.  With proper screening and monitoring liver cirrhosis is less of a risk.  Risk factors that may lead to toxicity include DM, obesity, metabolic syndrome, intake more than 3.5-4.0g of methotrexate, alcohol consumption more than 100g per week, and nonalcoholic steatohepatitis.

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