查看类风湿性关节炎管理中的DMARDs来源

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您请求的操作仅限于组中的用户:==简介==[[文件:Methotrexate.jpg|右|无边框]]]疾病修饰抗风湿药物(DMARDs)是一类用于治疗[[类风湿关节炎|类风湿关节炎]](RA)的药物,是一种病因不明的对称性、炎性、多发关节炎。dmard对于预防由类风湿性关节炎(RA)引起的关节畸形和损伤至关重要。[图片显示20世纪50年代早期使用的第一批化疗药物之一甲氨蝶呤]这些药物是免疫抑制剂,旨在减缓对关节的损害,它们可以诱导或维持缓解,减少发作的频率,并允许在维持疾病控制的同时逐渐减少类固醇的使用。它们也可用于治疗其他自身免疫性疾病,如[[硬皮病]]、[[脊柱炎]]、炎症性肌炎、炎症性肠病、[[系统性红斑狼疮]]。Benjamin O, Lappin SL. [https://www.ncbi.nlm.nih.gov/books/NBK507863/疾病调节抗风湿药物(DMARD)]。InStatPearls [Internet] 2019年1月6日StatPearls出版。本质上,它们干扰促进炎症的细胞信号级联反应Benjamin O.疾病修饰抗风湿药物(DMARD)。当前神经病学和神经科学报道。< nowiki > https://www.ncbi.nlm.nih.gov/books/NBK507863/ < / nowiki >。发布于2018年10月27日。确诊为类风湿性关节炎的患者在确诊后立即开始DMARD治疗可获得最佳预后Smolen JS, landewore R, Breedveld FC等。 EULAR recommendations for the management of rheumatoid arthritis with synthetic and biological disease-modifying antirheumatic drugs: 2013 update. Annals of the Rheumatic Diseases. https://ard.bmj.com/content/73/3/492. Published March 1, 2014.. Traditional DMARDs include methotrexate, leflunomide, hydroxychloroquine, and sulfasalazine. Others include cyclophosphamide, cyclosporine, and tacrolimus (FK506), but these are of limited use. Hydroxychloroquine (HCQ) and Methotrexate (MTX) are the most commonly used drugsSingh JA, Furst DE, Bharat A, et al. 2012 update of the 2008 American College of Rheumatology recommendations for the use of disease-modifying antirheumatic drugs and biologic agents in the treatment of rheumatoid arthritis. Current neurology and neuroscience reports. https://www.ncbi.nlm.nih.gov/pubmed/22473917. Published May 2012. This 3 minutes video gives a good overview {{#ev:youtube|https://www.youtube.com/watch?v=nR5EpuMxQSc&feature=youtu.be|width}}Marina Spyridis Design & Illustration DMARDs Available from: https://www.youtube.com/watch?v=nR5EpuMxQSc&feature=youtu.be (last accessed 30.12.2019)

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