查看利尿剂在高血压治疗中的来源

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您请求的操作仅限于组中的用户:有三种不同类型的利尿剂,包括噻嗪类利尿剂、循环利尿剂和保钾利尿剂。钾利尿剂用于充血性心力衰竭,并进行了讨论[[醛固酮受体拮抗剂利尿剂治疗充血性心力衰竭|这里]]。在这篇文章中,我们将特别关注噻嗪类和环利尿剂。利尿剂的主要作用部位是肾脏内的肾元。不同种类的利尿剂的特点是其不同的作用机制和特定的肾元靶向位置。噻嗪类利尿剂通过抑制钠重吸收作用于肾元远端小管。在这种抑制作用下,更多的钠留在肾元内,产生渗透力,使水保留在肾元内,并最终将水排出。降压药。《药理研究》2017;124年”,116 - 125。doi: 10.1016 / j.phrs.2017.07.026。 Thiazide diuretics are considered the drug of choice for long term treatment of hypertension by many physicians.Ernst ME, PharmD., & Moser M, M.D. (2009). Use of diuretics in patients with HypertensionDrug therapy:''N Engl J Med.'' 2009;361(22):2153-64. doi: http://dx.doi.org/10.1056/NEJMra0907219 * Loop diuretics, like thiazide diuretics, work to inhibit the reabsorption of sodium as well as chloride by targeting a sodium potassium chloride cotransporter, however they exert their effects in the ascending limb of the loop of Henle. By targeting these two specific electrolytes, loop diuretics prevent water reabsorption. The decrease in plasma volume that occurs in response to an increased sodium excretion reduces venous return and lowers cardiac output. [[File:Kidney nephron molar transport diagram.png|center|frameless|500x500px]]

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