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- 您请求的操作仅限于组中的用户:===医学治疗===急性脊髓损伤的理想治疗方法是结合[[脊髓损伤的药物治疗|药物治疗]]]治疗、早期手术、积极的体积复苏和血压升高以最大限度地提高脊髓灌注、早期康复和细胞治疗。 =====药物干预=====目前仍没有普遍接受的药物。最重要的候选药物是“[[皮质类固醇药物|糖皮质激素]]
s(甲基强的松龙)”,它抑制了许多脊髓损伤的“继发性”事件。它们是炎症、脂质过氧化和兴奋性毒性。随机临床试验的结果是矛盾的,专家的意见也是如此。zhang等,甲强的松龙在脊髓损伤治疗中的应用:来自随机对照试验的经验教训,中华外科杂志,2015;[6]: 142促甲状腺素释放激素(TRH)对继发性损伤介质具有拮抗作用。
有关更多信息,请参阅[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4303789/pdf/WJO-6-42.pdf文章]。“多不饱和脂肪酸(PUFA)如二十二碳六烯酸(DHA)”最近被探索用于脊髓损伤治疗。 It is said to improve neurological recovery through increased neuronal and oligodendrocyte survival and decreased microglia/macrophage responses, which reduces the axonal accumulation of B-Amyloid Precursor Protein (b-APP) and increases synaptic connectivity. Similarly ''Eicosapentaenoic Acid (EPA)'' increases synaptic connectivity, to restore neuro-plasticity.W.-Y. Yu et al., Current trends in spinal cord injury repair. Eur Rev Med Pharmacol Sci 2015; 19 (18): 3340-3344 ===== Surgical Intervention ===== Early surgical decompression results in a better neurological outcome. ===== Cellular Therapy Interventions ===== Traumatic SCI represents heterogeneous and complex pathophysiology. While pre-clinical research on SCI has been an ongoing endeavor for over a century, our understanding of SCI mechanisms has been increased remarkably over the past few decades. This is mainly due to the development of new transgenic and preclinical animal models that has facilitated rapid discoveries in SCI mechanisms. Although SCI research has made an impressive advancement, much work is still needed to translate the gained knowledge from animal studies to clinical applications in humans. The aim of cellular therapies is to provide functional recovery of the deficit through axonal regeneration and restoration.
''Schwann Cell is one of the most widely used cell types for the repair of the spinal cord.
''Olfactory Ensheating Cells'' are capable of promoting axonal regeneration and remyelination after injury.
''Bone Marrow derived Mononuclear Cells (BM-MNC’s) transplantation'' is feasible, safe, and has a good degree of outcome improvement.
''Stimulated Macrophages'' invade the impaired tissue.Yilmaz T., et al., Current and future medical therapeutic strategies for the functional repair of spinal cord injury, 2015, World J Orthop. 2015 Jan 18;6(1):42-55''